Design and construction of new metal-organic framework for antibacterial studies

Abstract

This report summarizes the synthesis of two linkers 5-(1-oxoisoindolin-2-yl)isophthalic acid (H2L) and 5-((2-carboxybenzyl)oxy)isophthalic acid (H3L). A substitution reaction was employed between diethyl-5-((2-cyanobenzyl)amino)isophthalate and 2-cyanobenzyl bromide in dry acetonitrile solvent using the alkaline medium to synthesize lactam based H2L linker. Moreover, the synthesis H3L linker was done by the substitution reaction of diethyl 5-((2-cyanobenzyl)oxy)isophthalate with 2-cyanobenzyl bromide. Both linkers H2L and H3L have been characterized by mass spectrometry, 1H, and 13C NMR spectroscopy. The H2L linker was reacted with 4,4’-azopy in the presence of Zn(NO3)2.6H2O under solvothermal conditions which gave rise to a Zn-MOF. This was characterized by SC-XRD, PXRD, SEM, EDS, TGA, and UV spectroscopy. Further, Ag was incorporated into the pores of Zn-MOF to get Ag@Zn-MOF which was characterized by PXRD, SEM, EDS, TGA, and UV spectroscopy. Also, the antibacterial studies were done for Zn-MOF and its composite against E. coli bacteria.