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| Title: | Key regulators of hepatic stellate cell activation in alcohol liver Disease: A comprehensive review |
| Authors: | Patidar, Pramod Bharti, Shreya Baig, Mirza Saqib |
| Keywords: | Alcoholic Liver Disease (ALD);Chronic Liver Disease (CLD);Hepatic Stellate Cells (HSCs);Liver Fibrosis (LF) |
| Issue Date: | 2024 |
| Publisher: | Elsevier B.V. |
| Citation: | Patidar, P., Hirani, N., Bharti, S., & Baig, M. S. (2024). Key regulators of hepatic stellate cell activation in alcohol liver Disease: A comprehensive review. International Immunopharmacology. Scopus. https://doi.org/10.1016/j.intimp.2024.112938 |
| Abstract: | Alcoholic liver disease (ALD) is a broad category of disorders that begin with liver injury, lead to liver fibrosis, and ultimately conclude in alcohol-induced liver cirrhosis, the most chronic and irreversible liver damage. Liver fibrosis (LF) is a common pathological characteristic observed in most chronic liver inflammatory conditions that involve prolonged inflammation. In this review, we have summarized ethanol-mediated hepatic stellate cell (HSCs) activation and its role in liver fibrosis progression. We highlight important molecular mechanisms that are modulated by ethanol, play a role in the activation of HSCs and the progression of liver fibrosis and identifying potential targets to ameliorate liver fibrosis. © 2024 |
| URI: | https://doi.org/10.1016/j.intimp.2024.112938 https://dspace.iiti.ac.in/handle/123456789/14575 |
| ISSN: | 1567-5769 |
| Type of Material: | Review |
| Appears in Collections: | Department of Biosciences and Biomedical Engineering |
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