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https://dspace.iiti.ac.in/handle/123456789/3833
| Title: | Herpesviruses and the hidden links to Multiple Sclerosis neuropathology |
| Authors: | Jakhmola, Shweta Jain, Khushboo Jha, Hem Chandra |
| Keywords: | alpha crystallin;autoantibody;beta crystallin;cytokine;epitope;membrane cofactor protein;myelin protein;virus antigen;B lymphocyte;CD4+ T lymphocyte;cell immortalization;Cytomegalovirus;disease association;Epstein Barr virus;Epstein Barr virus infection;Herpesviridae;host parasite interaction;human;Human alphaherpesvirus 1;Human endogenous retrovirus;Human herpesvirus 6;lymphocyte activation;molecular mimicry;multiple sclerosis;nonhuman;remyelinization;Review;signal transduction;Varicella zoster virus |
| Issue Date: | 2021 |
| Publisher: | Elsevier B.V. |
| Citation: | Jakhmola, S., Upadhyay, A., Jain, K., Mishra, A., & Jha, H. C. (2021). Herpesviruses and the hidden links to multiple sclerosis neuropathology. Journal of Neuroimmunology, 358 doi:10.1016/j.jneuroim.2021.577636 |
| Abstract: | Herpesviruses like Epstein-Barr virus, human herpesvirus (HHV)-6, HHV-1, VZV, and human endogenous retroviruses, have an age-old clinical association with multiple sclerosis (MS). MS is an autoimmune disease of the nervous system wherein the myelin sheath deteriorates. The most popular mode of virus mediated immune system manipulation is molecular mimicry. Numerous herpesvirus antigens are similar to myelin proteins. Other mechanisms described here include the activity of cytokines and autoantibodies produced by the autoreactive T and B cells, respectively, viral déjà vu, epitope spreading, CD46 receptor engagement, impaired remyelination etc. Overall, this review addresses the host-parasite association of viruses with MS. © 2021 Elsevier B.V. |
| URI: | https://doi.org/10.1016/j.jneuroim.2021.577636 https://dspace.iiti.ac.in/handle/123456789/3833 |
| ISSN: | 0165-5728 |
| Type of Material: | Review |
| Appears in Collections: | Department of Biosciences and Biomedical Engineering |
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