Please use this identifier to cite or link to this item:
https://dspace.iiti.ac.in/handle/123456789/3849
| Title: | Fusogenic viral protein-based near-infrared active nanocarriers for biomedical imaging |
| Authors: | Bishnoi, Suman Kumari, Anshu Rehman, Sheeba Nayak, Debasis Gupta, Sharad |
| Keywords: | Controlled drug delivery;Fluorescence imaging;Medical imaging;Targeted drug delivery;Theranostics;Viruses;Biomedical imaging;Drug delivery system;Fluorescence intensities;Indocyanine green dye;Intracellular delivery;Nir fluorescence imaging;Vesicular stomatitis virus;Viral nanoparticles;Infrared devices;beta actin;beta interferon;gamma interferon;indocyanine green;interferon regulatory factor 3;nanocarrier;virus glycoprotein;virus like nanoparticle;indocyanine green;nanoparticle;viral protein;absorption spectroscopy;animal experiment;animal tissue;Article;biocompatibility;cell viability;comparative study;controlled study;cytotoxicity;diagnostic imaging;dispersity;drug delivery system;drug release;drug stability;embryo;endosome;expression vector;female;fluorescence imaging;fluorescence intensity;gene expression;genetic transfection;HEK293T cell line;HeLa cell line;histopathology;human;human cell;hydrodynamics;immune response gene;in vitro study;innate immunity;internalization (cell);light exposure;molecular imaging;mouse;nanoencapsulation;nanofabrication;nanopharmaceutics;near infrared spectroscopy;NIH 3T3 cell line;nonhuman;particle size;photon correlation spectroscopy;plasmid;static electricity;transmission electron microscopy;ultraviolet visible spectrophotometry;Vesiculovirus;virus plaque;Western blotting;zeta potential;drug delivery system;fluorescence;Drug Delivery Systems;Fluorescence;Indocyanine Green;Nanoparticles;Viral Proteins |
| Issue Date: | 2021 |
| Publisher: | American Chemical Society |
| Citation: | Bishnoi, S., Kumari, A., Rehman, S., Minz, A., Senapati, S., Nayak, D., & Gupta, S. (2021). Fusogenic viral protein-based near-infrared active nanocarriers for biomedical imaging. ACS Biomaterials Science and Engineering, 7(7), 3351-3360. doi:10.1021/acsbiomaterials.1c00267 |
| Abstract: | An effective drug delivery system (DDS) relies on an efficient cellular uptake and faster intracellular delivery of theranostic agents, bypassing the endosomal mediated degradation of the payload. The use of viral nanoparticles (VNPs) permits such advancement, as the viruses are naturally evolved to infiltrate the host cells to deliver their genetic material. As a proof of concept, we bioengineered the vesicular stomatitis virus glycoprotein (VSV-G)-based near-infrared (NIR) active viral nanoconstructs (NAVNs) encapsulating indocyanine green dye (ICG) for NIR bioimaging. NAVNs are spherical in size and have the intrinsic cellular-fusogenic properties of VSV-G. Further, the NIR imaging displaying higher fluorescence intensity in NAVNs treated cells suggests enhanced cellular uptake and delivery of ICG by NAVNs compared to the free form of ICG. The overall study highlights the effectiveness of VSV-G-based VNPs as an efficient delivery system for NIR fluorescence imaging. © 2021 American Chemical Society. |
| URI: | https://doi.org/10.1021/acsbiomaterials.1c00267 https://dspace.iiti.ac.in/handle/123456789/3849 |
| ISSN: | 2373-9878 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Biosciences and Biomedical Engineering |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Altmetric Badge: