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| Title: | Water soluble two-photon fluorescent organic probes for long-term imaging of lysosomes in live cells and tumor spheroids |
| Authors: | Mobin, Shaikh M. |
| Keywords: | Article;bleaching;controlled study;crystallization;endocytosis;flow cytometry;human;human cell;hydrophilicity;image analysis;live cell imaging;lysosome;molecular probe;morphology;multiphoton microscopy;nuclear magnetic resonance spectroscopy;oxidative phosphorylation;protein localization;synthesis;tumor spheroid;water soluble two photon fluorescent organic probe;cell survival;chemical structure;chemistry;fluorescence;fluorescence imaging;HeLa cell line;lysosome;multicellular spheroid;pathology;photon;solubility;fluorescent dye;water;Cell Survival;Fluorescence;Fluorescent Dyes;HeLa Cells;Humans;Lysosomes;Molecular Structure;Optical Imaging;Photons;Solubility;Spheroids, Cellular;Water |
| Issue Date: | 2018 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Kumari, P., Verma, S. K., & Mobin, S. M. (2018). Water soluble two-photon fluorescent organic probes for long-term imaging of lysosomes in live cells and tumor spheroids. Chemical Communications, 54(5), 539-542. doi:10.1039/c7cc07812a |
| Abstract: | The morphological alteration of lysosomes is a powerful indicator of various pathological disorders. In this regard, we have designed and synthesized a new water soluble fluorescent Schiff-base ligand (L-lyso) containing two hydroxyl groups. L-lyso exhibits excellent two-photon properties with tracking of lysosomes in live cells as well as in 3D tumor spheroids. Furthermore, it can label lysosomes for more than 3 days. Thus, L-lyso has an edge over the commercially available expensive LysoTracker probes and also over other reported probes in terms of its long-term imaging, water solubility and facile synthesis. © 2018 The Royal Society of Chemistry. |
| URI: | https://doi.org/10.1039/c7cc07812a https://dspace.iiti.ac.in/handle/123456789/9080 |
| ISSN: | 1359-7345 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Chemistry |
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