Please use this identifier to cite or link to this item:
https://dspace.iiti.ac.in/handle/123456789/9097
| Title: | Metal- and Solvent-Free Approach to Diversely Substituted Picolinates via Domino Reaction of Cyclic Sulfamidate Imines with β,γ-Unsaturated α-Ketocarbonyls |
| Authors: | Biswas, Soumen Majee, Debashis Guin, Soumitra Samanta, Sampak |
| Keywords: | Reaction kinetics;Synthesis (chemical);Aza-heterocycles;Domino reactions;Eco-friendly;Functionalized;Imidazo[1 ,2-a]pyridine;Metal solvent;Rapid construction;Solvent free;Solvents;1,4 diazabicyclo[2.2.2]octane;carbonyl derivative;heterocyclic compound;imidazo[ 1,2 a]pyridine;imine;metal;picolinic acid derivative;pyridine derivative;solvent;sulfamide derivative;unclassified drug;annulation reaction;Article;arylation;chemical structure;cyclization;drug synthesis;microwave irradiation;organic chemistry;substitution reaction |
| Issue Date: | 2017 |
| Publisher: | American Chemical Society |
| Citation: | Biswas, S., Majee, D., Guin, S., & Samanta, S. (2017). Metal- and solvent-free approach to diversely substituted picolinates via domino reaction of cyclic sulfamidate imines with β,γ-unsaturated α-ketocarbonyls. Journal of Organic Chemistry, 82(20), 10928-10938. doi:10.1021/acs.joc.7b01792 |
| Abstract: | An efficient, solvent-free, and eco-friendly domino reaction of 5/6-membered cyclic sulfamidate imines with a variety of β, γ-unsaturated α-ketocarbonyls in neat conditions under MW irradiation promoted by DABCO as a solid organobase has been developed for the rapid construction of a novel class of densely functionalized picolinates. This interesting metal-solvent-free tactic allows a wide range of useful functionalities on the aryl rings and delivers good to excellent yields of the aforesaid aza-heterocycles within short time spans (20-40 min). A biologically promising imidazo[1,2-a]pyridine was successfully synthesized through our unique procedure. © 2017 American Chemical Society. |
| URI: | https://doi.org/10.1021/acs.joc.7b01792 https://dspace.iiti.ac.in/handle/123456789/9097 |
| ISSN: | 0022-3263 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Chemistry |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Altmetric Badge: